Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disorder caused by various mutations in the gene encoding the key glycolytic enzyme TPI. A drastic decrease in TPI activity and an increased level of its substrate. dihydroxyacetone phosphate. have been measured in unpurified cell extracts of affected individuals. https://www.parisnaturalfoodes.shop/product-category/manuka-honey-100mgo/