Niemann-Pick C (NPC) disease is an autosomal recessive disorder that leads to excessive storage of cholesterol and other lipids in late endosomes and lysosomes. The large majority of NPC disease is caused by mutations in NPC1. a large polytopic membrane protein that functions in late endosomes. There are many disease-associated mutations in NPC1. https://www.ngetikin.com/great-pick-Borstlist-sjalvhaftande-Tesa-hot-grab/