ABSTRACT The molecular mechanisms underlying how SUD2 recruits other proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to exert its G-quadruplex (G4)-dependent pathogenic function is unknown. Herein. Nsp5 was singled out as a binding partner of the SUD2-N+M domains (SUD2core) with high affinity. through the surface located crossing these two domains. https://www.knowall.blog/