Under normal homeostatic conditions. hepatocyte renewal is a slow process and complete turnover likely takes at least a year. Studies of hepatocyte regeneration after a two-thirds partial hepatectomy (2/3 PH) have strongly suggested that periportal hepatocytes are the driving force behind regenerative re-population. but recent murine studies have brought greater complexity to the issue. https://www.roneverhart.com/Boxing-Pop-Vinyl-Figure-Ryan-Garcia-04/